Table 4.
Cross-sectional and longitudinal adjusted associations between adiposity markers and secondary outcomes SDMT
| UNIVARIATE ASSOCIATIONS | MULTIVARIATE ASSOCIATIONS | |||||
|---|---|---|---|---|---|---|
| All subjects | Women | Men | All subjects | Women | Men | |
| Cross-sectional SDMT (N=65) – positive score indicates better function | ||||||
| Adiposity Markers | ||||||
| Leptin | −0.01 (0.90) | −0.04 (0.70) | 0.15 (0.76) | - | - | - |
| a-FABP | −0.13 (0.092) | −0.12 (0.16) | −0.15 (0.58) | −0.11 (0.15) | −0.11 (0.16) | −0.11 (0.68) |
| Additional markers | ||||||
| 25(OH)VitD | 0.25 (0.058) | 0.27 (0.087) | 0.029 (0.93) | 0.24 (0.076) | 0.28 (0.087) | −0.015 (0.96) |
| Testosterone | 0.002 (0.82) | 0.005 (0.97) | 0.019 (0.23) | 0.002 (0.73) | 0.056 (0.66) | 0.018 (0.27) |
| Longitudinal SDMT (N=96)* - a positive value indicates less worsening in function | ||||||
| Adiposity Markers | ||||||
| Leptin | −0.007 (0.57) | 0.031 (0.042) | −0.0075 (0.90) | 0.019 (0.20) | 0.031 (0.057) | −0.0042 (0.94) |
| a-FABP | 0.007 (0.58) | 0.030 (0.055) | 0.0073 (0.79) | - | - | - |
| Additional markers | ||||||
| 25(OH)VitD | −0.0009 (0.96) | 0.006 (0.74) | −0.015 (0.79) | 0.0078 (0.64) | −0.004 (0.83) | −0.022 (0.70) |
| Testosterone | 0.0039 (<0.001) | 0.011 (0.64) | 0.0040 (0.056) | 0.0048 (<0.001) | −0.004 (0.87) | 0.0040 (0.060) |
*
: Random intercept only model was used for the SDMT because of problems fitting random intercept and slope model for some of the predictors.
Cross-sectional analyses: Increase in mean score for one unit increase in each of the hormone measures (p-value). Adjusted for age, disease duration and type. SDMT analyses also adjusted for CES-D.
Longitudinal analyses: Estimate and p-value of the association between hormonal markers and change in score over time are provided. Adjusted for age, disease duration and type. SDMT analyses also adjusted for CES-D.