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. Author manuscript; available in PMC: 2018 Jul 12.
Published in final edited form as: Nat Methods. 2018 Jan 1;15(2):107–114. doi: 10.1038/nmeth.4540

Figure 4.

Figure 4

Functional properties of predicted interfaces. (a) Enrichment of disease mutations in predicted and known interfaces. In a–c, enrichment (log odds ratio) is the odds of mutations and variants to appear in and outside of predicted and known interfaces compared to the odds of any residues to exist in these categories. (b) Enrichment of recurrent cancer mutations in predicted and known interfaces. (c) Enrichment of rare and common population variants in predicted and known interfaces. (d, e) Predicted deleteriousness of population variants in known and predicted interfaces using PolyPhen-2 (d) or EVmutation (e). (In b, significance determined by two-sided Z-test. In d-e, significance determined by a two-sided U-test. IRES=interface residues)