Table 1.
PF403- and TMZ-mediated inhibition of proliferation in TMZ-resistant glioblastoma cells
| Time (hours) | IC50 (mol/L)
|
|||
|---|---|---|---|---|
| U251/TMZ
|
T98G
|
|||
| PF403 | TMZ | PF403 | TMZ | |
| 24 | 3.20 ± 0.64 × 10−5 | >1 × 10−3 | 3.47 ± 1.24 × 10−5 | >1 × 10−3 |
| 48 | 2.73 ± 1.37 × 10−8 | >1 × 10−3 | 1.49 ± 0.95 × 10−6 | >1 × 10−3 |
| 72 | 4.14 ± 1.08 × 10−12 | >1 × 10−3 | 1.79 ± 0.82 × 10−9 | >1 × 10−3 |
Note: Data are presented as mean ± standard deviation.
Abbreviations: IC50, half maximal inhibitory concentration; PF403, 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine; TMZ, temozolomide.