Fig. 3.

Global protein profile analysis. a Protein abundances were log2 transformed and ratios between drug treated and untreated calculated. There are treatment conditions with little change in protein abundance as a result of treatment, e.g., BEZ or BEZ + MK2, while other treatment conditions have a profound effect on short-term protein abundance changes following treatment, e.g., DAS + ENZ or ENZ + MK2 (for drug abbreviations, see caption of Fig. 1). b Principle component analysis (PCA) of protein abundance changes groups DOC treatment conditions and identifies ENZ + MK2 as distinct double treatment condition (red circle)