Fig. 4.

Protein centric view of abundance ratio across conditions. a Predominantly upregulated proteins such as enzymes (e.g., KLK2) and chaperons (e.g., 14-3-3 proteins) as short-term response to pharmacological conditions tested in LNCaP cells. b Frequently investigated proteins in PCa (e.g., KLK3 [PSA] or HSP90) show little change in protein abundance across the tested pharmacological perturbations in LNCaP cells. c Predominantly down-regulated proteins as short-term response to pharmacological conditions tested. Proteins such as PAK1 and HN1 are poorly characterized in PCa