Fig. 5.

Genomic alterations in PCa patients. a Genomic alterations of 333 primary PCa specimens. Each bar represents a patient. In blue are deep gene deletions, while in red are gene amplifications. Clearly visible are three sub-groups: FOXO1 deletions (14%), PTEN deletions (17%), and YWHAZ amplifications (7%, indicated by red asterisks). b Genomic alterations of an independent 150 metastatic CRPC querying the same genes as in a. Consistent with prior knowledge is the AR gene amplification in 51% of patient samples and PTEN deletion in 51% of cases. YWHAZ is amplified in 27% of metastatic castration-resistant PCa, a four-fold increase over primary localized PCa patients