Table 1.
Effects of GluA1(Q600R) on locomotor activity and spatial working memory during the spontaneous alternation T-maze test.
| Task/Measure |
WT Male |
WT Female |
Gria1R/R Male |
Gria1R/R Female |
Statistics (effect of genotype) |
|---|---|---|---|---|---|
| Spontaneous locomotor activity | |||||
| Total beam breaks (2 h) | 2861 ± 419 | 2355 ± 295 | 4246 ± 431 | 4572 ± 439 | F(1,25) = 18.0; p < 0.01 |
| Spontaneous alternation | |||||
| % alternation | 87.5 ± 3.1 | 71.7 ± 7.0 | 61.1 ± 5.9 | 43.3 ± 8.0 | F(1,25) = 20.4; p < 0.01 |
WT littermates (n = 14) and Gria1R/R mice (n = 15). Data are presented as means (± SEM) and were analyzed by analysis of variance. Where necessary data were subjected to log10 transformation prior to analysis.