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. 2018 Jun 25;9:1459. doi: 10.3389/fimmu.2018.01459

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Copyright © 2018 Dennhardt, Pirschel, Wissuwa, Daniel, Gunzer, Lindig, Medyukhina, Kiehntopf, Rudolph, Zipfel, Gunzer, Figge, Amann and Coldewey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in renal gene expression in response to different Stx2 regimens. (A) Heat map of features obtained from ANOVA filtering adjusted p < 0.05 comprising z-score scaled values. In each group, n = 4 animals were studied. (B) Proportional Venn diagram of differentially expressed genes according to the limit fold change for acute (dark gray) vs. subacute model (light gray). Number of overlapping genes is highlighted in white. Gene expression data were filtered for candidate genes from complement pathway. Log2 signals for (C) complement C3a receptor 1 (C3ar1), (D) complement factor C3 (C3), (E) complement C1q B chain (C1qb), and (F) tissue factor (F3) are illustrated by box plots.