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. 2018 Jun 25;9:1487. doi: 10.3389/fimmu.2018.01487

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Copyright © 2018 Johnzon, Dahlberg, Gustafson, Waern, Moazzami, Östensson and Pejler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Score plot of the partial least-squares analysis (PLS) model fitted to compare plasma metabolic profile between lipopolysaccharide (LPS) and control group. Plasma was recovered from LPS-infused and control animals followed by metabolomics analysis. (A) Profile at 4 h. Model parameter for one component fitted were as follow: R²Y = 0.86; Q² = 0.74; cross-validated ANOVA, p = 0.03. Below control, above LPS samples. (B) Profile at 24 h. Model parameter for three components fitted were as follow: R²Y = 0.98; Q² = 0.93; cross-validated ANOVA, p = 0.08. Left control, right LPS samples.