Table 1. Effects of CS exposure on murine models of MTB infection.
Murine cell type | Findings in CS-exposed mice compared to air-exposed mice |
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Macrophages | Reduced number of IL-12 and TNFα-positive splenic and lung macrophages; increased number of IL-10-positive splenic macrophages (40). |
Dendritic cells | Reduced number of IL-12 and TNFα-positive splenic and lung dendritic cells; increased number of IL-10-positive splenic dendritic cells (40). |
T effector cells | Reduced number of TH1 cells with reduced IFNγ production per cell (38,39,40); also reduced influx of IFNγ and TNFα-positive CD4+ and CD8+ T cells into the lungs and spleens (38,40); increased influx of IL-4-positive TH2 cells in the lungs (39); CS also impaired (DNA) vaccinated mice to MTB-specific antigen by reducing the number of antigen-specific TH1 cells (38). |