FIG 9.

Origin of virus in male genital organs and semen. (A) Model for virus seeding in male genital organs: virus in male genital organs may originate from blood (1), from another genital organ as a result of close vicinity or connected vasculature system (as observed between vas deferens, epididymis body, and testis in macaque H1) (2), or from a distant genital organ by transmission via semen, as suggested for urethra in macaque H1 and H2 (3). (B) Scheme illustrating the male genital organs releasing virus in semen for 2 macaques with compartmentalized strains in semen.