TABLE 3.
Summary of biological properties of BR constructsa
| BR construct | AAP level | VP level | Vector yield | AAP localization |
|---|---|---|---|---|
| AAP1 WT | WT | WT | WT | Nucleolus |
| DBR | ++++ | WT | − − | Cytoplasmic |
| 4BR | +++++ | + | + | Nucleolus |
| 5BR | +++++ | WT | − | Nucleus |
| 9BR | +++ | − | − − | Nucleus |
| Rpp29 | ++++ | − | − | Nucleus/nucleolus |
| AP3D1 | ++++ | WT | WT | Nucleolus |
| SV40 | ++++ | + | − − | Nucleus |
| HIV Rev | ++++ | − | − | Nucleolus |
a
WT represents similar properties, “−” represents reduced levels, and “+” represents increased levels compared to AAP1 WT. The numbers of “+” and “−” are proportional to the increase or decrease in expression level or titer.