FIG 5.

Immunohistochemical and H&E staining of the caudate nucleus from CM121. (A and B) Anti-PrP staining with the 3F4 antibody (A) and anti-PrP staining with the 6H4 antibody (B) show a cluster of PrP staining (brown). Several additional similar clusters were observed in the caudate nucleus of this monkey. (C) H&E staining of the same region depicted in panels A and B. No spongiform lesions were observed. (D) Minimal anti-GFAP staining and a lack of astrocytic activation in the same brain regions shown in panels A and B. The bar shown in panel A is 25 μm and applies to all panels.