TABLE 2.
RT-QuIC of cynomolgus macaque brain and spinal cord samples using the BV rPrPsen substratea
| Monkey | Inoculum | Route | Yr postinfection | Sample result |
||||
|---|---|---|---|---|---|---|---|---|
| Brain |
Spinal cord |
|||||||
| Cerebral cortex | Brain stem (pons) | Cervical | Thoracic | Lumbar | ||||
| 16999 | vCJD | i.p. | 2.4 | + | TNA | TNA | TNA | TNA |
| 7422 | vCJD | i.p. | 2.4 | + | TNA | TNA | TNA | TNA |
| 7423 | vCJD | i.p. | 2.3 | + | TNA | TNA | TNA | TNA |
| 116 | WTD | i.c. | 7.3 | − | − | − | − | − |
| 144 | WTD | i.c. | 6.6 | − | − | − | − | − |
| 128 | Elk | i.c. | 13.4 | − | − | NT | NT | NT |
| 616 | Elk | i.c. | 7.9 | − | − | − | − | − |
| 609 | MD | i.c. | 4.0 | − | − | − | − | − |
| 135 | MD | i.c. | 13.3 | − | − | − | NT | NT |
| 119 | WTD | Oral | 13.3 | − | − | − | NT | NT |
| 125 | WTD | Oral | 8.8 | − | − | − | − | − |
| 130 | Elk | Oral | 12.4 | − | − | NT | − | NT |
| 629 | Elk | Oral | 13.1 | − | − | − | NT | NT |
| 121 | Elk | Oral | 10.9 | − | − | − | NT | − |
| 270 | MD | Oral | 8.8 | − | − | − | − | − |
| 122 | MD | Oral | 8.1 | − | − | − | − | − |
| 614 | MD | Oral | 11.8 | − | − | − | − | − |
| 633 | NEB | i.c. | 8.1 | − | − | − | − | − |
| 228 | None | NA | − | − | − | − | − | |
| 949 | None | NA | − | − | − | − | − | |
| 585 | None | NA | − | − | − | − | − | |
| 151 | None | NA | − | − | TNA | TNA | TNA | |
| 146 | None | NA | − | − | TNA | TNA | TNA | |
| 27 | None | NA | − | TNA | TNA | TNA | TNA | |
a
Abbreviations: vCJD, variant Creutzfeldt-Jacob disease; i.p., intraperitoneal; TNA, tissue not available; WTD, white-tailed deer CWD; i.c., intracerebral; NT, not tested; MD, mule deer CWD; NEB, normal elk brain; NA, not applicable.