Figure 3.
Calculated minimal concentration required for H-aggregate formation in MCH for a system in which the cooperative polymerization is in competition with an isodesmic pathway (a) and a system that can only polymerize via a single cooperative pathway supramolecular polymerization (b). The shaded area indicates the presence of cooperative polymers. In the case of a competitive system (a), the minimum concentration required for the formation of H-aggregates explodes when the solvent composition is such that ΔGcoop= ΔGiso. For the single cooperative pathway, aggregates can form at any solvent composition. The thermodynamic parameters obtained from the denaturation experiment of 1 μM were used in the calculation.