Table 2.
Multivariable Cox regression analysis of RFS in HCC patients in the training, testing, and entire sets
| Characteristic | Multivariable analysis | ||
|---|---|---|---|
| HR | 95% CI of HR | P‐value | |
| Training set (n = 153) | |||
| Risk score | 1.623 | 1.346–1.966 | < 0.0001 |
| Sex, female/male | 1.008 | 0.625–1.625 | 0.974 |
| Age (years), ≥ 65/< 65 | 0.767 | 0.4634–1.271 | 0.304 |
| Tumor stage, III.IV/I.II | 15.280 | 1.579–147.89 | 0.019 |
| Tumor grade, III.IV/I.II | 0.897 | 0.552–1.457 | 0.660 |
| T stage, T3.T4/T1.T2 | 0.124 | 0.013–1.178 | 0.069 |
| N stage, non‐N0/N0 | 1.665 | 0.906–3.059 | 0.101 |
| M stage, non‐M0/M0 | 0.952 | 0.505–1.792 | 0.878 |
| Testing set (n = 153) | |||
| Risk score | 1.378 | 1.101–1.701 | 0.004 |
| Sex, female/male | 0.580 | 0.333–1.011 | 0.055 |
| Age (years), ≥ 65/< 65 | 1.211 | 0.721–2.033 | 0.470 |
| Tumor stage, III.IV/I.II | 1.330 | 0.158–11.21 | 0.793 |
| Tumor grade, III.IV/I.II | 1.362 | 0.826–2.240 | 0.227 |
| T stage, T3.T4/T1.T2 | 2.468 | 0.211–16.073 | 0.581 |
| N stage, non‐N0/N0 | 0.843 | 0.376–1.582 | 0.479 |
| M stage, non‐M0/M0 | 1.022 | 0.631–2.298 | 0.574 |
| Entire set (n = 306) | |||
| Risk score | 1.484 | 1.298–1.696 | < 0.0001 |
| Sex, female/male | 0.739 | 0.514–1.061 | 0.101 |
| Age, years, ≥ 65/< 65 | 0.916 | 0.647–1.296 | 0.621 |
| Tumor stage, III.IV/I.II | 1.625 | 0.374–7.061 | 0.517 |
| Tumor grade, III.IV/I.II | 1.074 | 0.766–1.504 | 0.680 |
| T stage, T3.T4/T1.T2 | 1.230 | 0.278–5.441 | 0.785 |
| N stage, non‐N0/N0 | 1.028 | 0.661–1.598 | 0.904 |
| M stage, non‐M0/M0 | 1.239 | 0.803–1.910 | 0.332 |
Tumor grade: neoplasm histologic grade; Tumor stage: AJCC pathological stage; T stage: tumor size; N stage: lymph node involvement; M stage: metastasis status. Values in bold indicate they are statistically different.