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. 2018 May 21;12(7):1026–1046. doi: 10.1002/1878-0261.12308

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© 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Model of SALL2‐dependent regulation of the cell cycle. SALL2 directly inhibits G1‐S phase progression by repressing cyclin D1 and cyclin E1 expression (this article). Additionally, SALL2 induces p21^CIF ^/ ^WAF (p21) and p16^INK ^4a (p16) and represses c‐Myc. As c‐Myc represses p21, SALL2‐mediated c‐Myc repression could indirectly increase p21 levels. As Myc could trigger cyclin E1 and D1 expression, SALL2 could indirectly downregulate cyclins by repressing c‐Myc. Dotted arrow indicates indirect effects.