Table 5.
Crude and adjusteda odds ratios (ORs) of the medical histories of the parents of women with polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) or both compared with healthy controls (n = 1941).
Characteristic | OR (95% CI) | |||||
---|---|---|---|---|---|---|
GDM + PCOS (n = 105) | GDM + non-PCOS (n = 909) | Non-GDM + PCOS (n = 69) | ||||
Crude | Adjusteda | Crude | Adjusteda | Crude | Adjusteda | |
Pregnancy history of participants’ mothersb | ||||||
GDMc | 1.37 (0.30–6.15) | 1.80 (0.34–9.44) | 1.92 (0.97–3.78) | 1.86 (0.89–3.91) | 0.95 (0.12–7.38) | 0.98 (0.12–7.68) |
GDM at any pregnancy | 1.52 (0.62–3.73) | 2.30 (0.82–6.48) | 2.49 (1.63–3.79) | 3.25 (2.04–5.18) | 0.81 (0.19–3.46) | 0.95 (0.22–4.15) |
Pre-eclampsiac | 1.85 (0.80–4.30) | 1.48 (0.58–3.75) | 1.27 (0.81–1.99) | 0.94 (0.57–1.55) | 0.34 (0.05–2.51) | 0.27 (0.04–2.00) |
Medical history of participants’ mothersb | ||||||
Diabetes mellitus | 2.76 (1.51–5.03) | 2.16 (1.06–4.40) | 2.72 (1.95–3.81) | 1.87 (1.29–2.72) | 1.58 (0.65–3.83) | 1.41 (0.57–3.46) |
Hypertension | 1.32 (0.83–2.12) | 1.27 (0.74–2.16) | 1.46 (1.13–1.83) | 1.23 (0.96–1.57) | 0.91 (0.49–1.71) | 0.90 (0.48–1.72) |
Myocardial infarction | 1.09 (0.25–4.83) | 0.39 (0.06–2.59) | 0.81 (0.38–1.72) | 0.43 (0.18–1.04) | 1.78 (0.40–7.98) | 1.27 (0.27–5.96) |
Stroke | 0.58 (0.08–4.48) | 0.78 (0.09–6.79) | 1.76 (0.91–3.40) | 1.36 (0.65–2.83) | 3.89 (1.24–12.2) | 3.74 (1.16–12.0) |
Medical history of participants’ fathersb | ||||||
Diabetes mellitus | 2.41 (1.46–3.97) | 1.76 (0.99–3.11) | 1.66 (1.26–2.18) | 1.26 (0.94–1.71) | 1.11 (0.51–2.39) | 1.03 (0.47–2.26) |
Hypertension | 1.46 (0.91–2.33) | 1.36 (0.80–2.30) | 1.50 (1.20–1.87) | 1.22 (0.95–1.57) | 1.54 (0.87–2.74) | 1.46 (0.81–2.62) |
Myocardial infarction | 1.19 (0.61–2.32) | 0.80 (0.36–1.78) | 1.11 (0.81–1.53) | 0.86 (0.60–1.23) | 0.86 (0.33–2.20) | 0.88 (0.34–2.28) |
Stroke | 0.83 (0.25–2.78) | 0.82 (0.20–3.43) | 1.52 (0.95–2.43) | 1.50 (0.88–2.54) | 0.93 (0.22–3.97) | 1.05 (0.24–4.56) |
aLogistic regression for categorical variables adjusted for participants’ parity, smoking during pregnancy, educational attainment, delivery hospital, age and pre-pregnancy BMI; bas reported by the participants at recruitment in this study; cduring the pregnancy when the study participant was born.