Figure 3.

Family pedigrees for probands 1 (A), 2 (B), 3 (C), 4 (D), and 5 (E), respectively. ‘I, II, III’ represent generations, ‘□, ○’ indicate normal males and females, ‘●, ■’ represent male and female carriers of the corresponding VHL mutation, dashes between symbols ‘□–○’ indicate a couple and ‘↗’ indicates the probands.