Table 2.

Patients’ hormone expression profiles.

Hormone	Reference range	Proband 4	Proband 5
Cortisol 8 (ng/mL)	50–280	241	312
Cortisol 16 (ng/mL)	20–140	135	381
Cortisol 24 (ng/mL)	10–120	81	128
ACTH 8 (pg/mL)	5.08–32.8	16.9	—
ACTH 16 (pg/mL)	10.7–30.5	24.0	—
ACTH 24 (pg/mL)	5–15	12.5	—
Vanillylmandelic acid (μmol/24 h urine)	9.6–50.0	28.1	116.8
17-Hydroxycorticosteroid (μmol/24 h urine)	5.5–33.2	16.4	11.3
17-Ketosteroid (μmol/24 h)	13.9–76.3	67.2	40
Orthostatic aldosterone (ng/mL)	0.1–0.3	0.1	0.1
Clinostatic aldosterone (ng/mL)	0.1–0.2	0.1	0.2
Orthostatic renin activity (ng/mL/h)	0.3–5.2	3.4	17.9
Clinostatic renin activity (ng/mL/h)	0.1–1.5	1.0	17.1
Orthostatic angiotensin II (pg/mL)	19–115	79	322
Orthostatic angiotensin II (pg/mL)	15–97	55	306
Hypertension		No	Yes

ACTH, adrenocorticotropic hormone.