Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for the retention pathway in adipocytes. VpTR, the TR, and GLUT4 are internalized from the plasma membrane and delivered to the ERC. Two classes of vesicles bud from the ERC. The TR recycles rapidly in one class of vesicle. In fibroblasts, vesicles containing vpTR and GLUT4 recycle slowly from the ERC, whereas in adipocytes, these vesicles are tethered inside the cell, forming a separate retention compartment. SE, sorting endosome; PM, plasma membrane.
