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Nucleation induction time for pure ITZ, Sporanox®, and different formulations in simulated intestinal fluid. (A) Nucleation induction time for pure ITZ (itraconazole), Sporanox®, and ASD (amorphous solid dispersion) without surfactant; Nucleation induction time for ASD with different amount of (B) TPGS (d-α-tocopheryl polyethylene glycol 1000 succinate), (C) SDS (sodium dodecyl sulfate), and (D) Poloxamer 188.
