Table 2.
Outcome | Model | n | Age | Gender | Education | Aβ | Tau | Aβ*age |
---|---|---|---|---|---|---|---|---|
AVLT Immediate | Model 1 | 623 | −0.44 ± 0.06*** | −5.63 ± 0.73*** | 0.41 ± 0.11*** | |||
Model 2 | 623 | −0.43 ± 0.06*** | −5.64 ± 0.73*** | 0.40 ± 0.11*** | −0.99 ± 0.82 | |||
Model 3 | 318 | −0.38 ± 0.08** | −5.62 ± 1.09*** | 0.92 ± 0.19*** | −0.26 ± 1.08 | −0.74 ± 1.43 | ||
Model 4 | 318 | −0.54 ± 0.11*** | −5.67 ± 1.08*** | 0.91 ± 0.19*** | 20.51 ± 10.53* | −0.33 ± 1.44 | −0.29 ± 0.14* | |
AVLT delayed | Model 1 | 621 | −0.12 ± 0.02*** | −1.49 ± 0.26*** | 0.07 ± 0.04 | |||
Model 2 | 621 | −0.12 ± 0.02*** | −1.49 ± 0.26*** | 0.07 ± 0.04 | −0.41 ± 0.30 | |||
Model 3 | 317 | −0.14 ± 0.03** | −1.09 ± 0.42* | 0.17 ± 0.08* | −0.27 ± 0.41 | −0.61 ± 0.55 | ||
Model 4 | 317 | −0.20 ± 0.04*** | −1.10 ± 0.41** | 0.16 ± 0.07* | 8.87 ± 4.08* | −0.43 ± 0.55 | −0.13 ± 0.06* | |
VFT | Model 1 | 716 | −0.16 ± 0.03*** | −0.20 ± 0.41 | 0.36 ± 0.06*** | |||
Model 2 | 716 | −0.16 ± 0.03*** | −0.18 ± 0.41 | 0.35 ± 0.06*** | 0.41 ± 0.48 | |||
Model 3 | 414 | −0.20 ± 0.04*** | −0.07 ± 0.53 | 0.39 ± 0.08*** | 0.60 ± 0.56 | −0.50 ± 0.75 | ||
TMT-A | Model 1 | 904 | 0.69 ± 0.06*** | 0.81 ± 0.85 | −0.71 ± 0.12*** | |||
Model 2 | 904 | 0.67 ± 0.06*** | 0.89 ± 0.85 | −0.70 ± 0.12*** | 2.25 ± 1.01** | |||
Model 3 | 567 | 0.61 ± 0.08*** | −0.50 ± 1.08 | −0.75 ± 0.17*** | 3.53 ± 1.21** | −0.73 ± 1.63 | ||
TMT-B | Model 1 | 898 | 1.70 ± 0.16*** | 2.27 ± 2.22 | −2.20 ± 0.32*** | |||
Model 2 | 898 | 1.63 ± 0.16*** | 2.52 ± 2.21 | −2.17 ± 0.32*** | 7.47 ± 2.61** | |||
Model 3 | 563 | 1.48 ± 0.20*** | −0.66 ± 2.77 | −2.16 ± 0.43*** | 10.24 ± 3.11** | −2.38 ± 3.11 | ||
Model 4 | 563 | 1.97 ± 0.30*** | −0.71 ± 2.77 | −2.16 ± 0.43*** | −38.73 ± 22.74 | −3.39 ± 4.17 | 0.70 ± 0.32* |
Numbers are mixed model coefficients ± standard error.
p < 0.05,
p < 0.01,
p < 0.001. Model 4 was only added when any of the two-way interactions were significant. Aβ, amyloid-beta; AVLT, Auditory Verbal Learning Test; TMT-A, Trail Making Test part A; TMT-B, Trail Making Test part B; VFT, verbal fluency test.