Table 2.

Stepwise testing of linear mixed models including CSF biomarkers to predict cognitive test performance.

Outcome	Model	n	Age	Gender	Education	Aβ	Tau	Aβ*age
AVLT Immediate	Model 1	623	−0.44 ± 0.06***	−5.63 ± 0.73***	0.41 ± 0.11***
	Model 2	623	−0.43 ± 0.06***	−5.64 ± 0.73***	0.40 ± 0.11***	−0.99 ± 0.82
	Model 3	318	−0.38 ± 0.08**	−5.62 ± 1.09***	0.92 ± 0.19***	−0.26 ± 1.08	−0.74 ± 1.43
	Model 4	318	−0.54 ± 0.11***	−5.67 ± 1.08***	0.91 ± 0.19***	20.51 ± 10.53*	−0.33 ± 1.44	−0.29 ± 0.14*
AVLT delayed	Model 1	621	−0.12 ± 0.02***	−1.49 ± 0.26***	0.07 ± 0.04
	Model 2	621	−0.12 ± 0.02***	−1.49 ± 0.26***	0.07 ± 0.04	−0.41 ± 0.30
	Model 3	317	−0.14 ± 0.03**	−1.09 ± 0.42*	0.17 ± 0.08*	−0.27 ± 0.41	−0.61 ± 0.55
	Model 4	317	−0.20 ± 0.04***	−1.10 ± 0.41**	0.16 ± 0.07*	8.87 ± 4.08*	−0.43 ± 0.55	−0.13 ± 0.06*
VFT	Model 1	716	−0.16 ± 0.03***	−0.20 ± 0.41	0.36 ± 0.06***
	Model 2	716	−0.16 ± 0.03***	−0.18 ± 0.41	0.35 ± 0.06***	0.41 ± 0.48
	Model 3	414	−0.20 ± 0.04***	−0.07 ± 0.53	0.39 ± 0.08***	0.60 ± 0.56	−0.50 ± 0.75
TMT-A	Model 1	904	0.69 ± 0.06***	0.81 ± 0.85	−0.71 ± 0.12***
	Model 2	904	0.67 ± 0.06***	0.89 ± 0.85	−0.70 ± 0.12***	2.25 ± 1.01**
	Model 3	567	0.61 ± 0.08***	−0.50 ± 1.08	−0.75 ± 0.17***	3.53 ± 1.21**	−0.73 ± 1.63
TMT-B	Model 1	898	1.70 ± 0.16***	2.27 ± 2.22	−2.20 ± 0.32***
	Model 2	898	1.63 ± 0.16***	2.52 ± 2.21	−2.17 ± 0.32***	7.47 ± 2.61**
	Model 3	563	1.48 ± 0.20***	−0.66 ± 2.77	−2.16 ± 0.43***	10.24 ± 3.11**	−2.38 ± 3.11
	Model 4	563	1.97 ± 0.30***	−0.71 ± 2.77	−2.16 ± 0.43***	−38.73 ± 22.74	−3.39 ± 4.17	0.70 ± 0.32*

Numbers are mixed model coefficients ± standard error.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001. Model 4 was only added when any of the two-way interactions were significant. Aβ, amyloid-beta; AVLT, Auditory Verbal Learning Test; TMT-A, Trail Making Test part A; TMT-B, Trail Making Test part B; VFT, verbal fluency test.