Figure 3.

HhN domains are present in bacteria. Lineup of several hypothetical proteins in bacteria, Hedgling and metazoan Hhs. The conserved domain (HhN, green box, about 175 residues) is flanked by other sequences in the various species. In bacteria (yellow box) the HhN domain is the C-terminal end of the hypothetical proteins. The HhN domain is the N-terminal part of Hedgling and Hhs (red box). The blue and red lines indicate medium and high levels of conservation. Accession numbers of the aligned proteins are in the Supplementary file.