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Density, molar mass, solubility, and pKa of the drug and AAs used in this study [9]. a Solubility of indomethacin based on phosphate buffer pH 7.2 [26].
| Chemical Substances | Density (g/cm3) | Molar Mass (g/mol) | Water Solubility (mg/mL) | pKa |
|---|---|---|---|---|
| Indomethacin | 1.379 | 357.79 | 0.75 a | 4.5 |
| Arginine | 1.325 | 174.2 | 50 | 12.48 |
| Histidine | 1.412 | 155.15 | 41.6 | 6.04 |
| Lysine | 1.237 | 146.2 | 100 | 10.79 |
