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. 2018 Apr 10;6(2):43. doi: 10.3390/biomedicines6020043

Figure 1.

Figure 1

The NF-κB proteins and their inhibitors. (A) Members of the Rel/NF-κB family. The five NF-κB subunits are presented with their functional domains. RHD = Rel homology domain; TAD = transcription activation domain; LZ = leucine zipper; GR = glycine-rich domain; DD = death domain. The bold arrows indicate the C-terminus of p50 and p52 after processing of p105 and p100, respectively. (B) Members of the IκB family. The three IκB inhibitors are presented with their functional domains. PEST = proline/glutamic acid/serine/threonine-rich sequence.