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Schematic representation of the assembly of DOTA-OP3-4 by SPPS. Numbered sections indicate the order of assembly. The numbers used refer to: (1) the attachment of the rink amide linker; (2) the coupling of Fmoc lys (Mtt)–OH; (3) the removal of Mtt groups followed by the coupling of DOTA-Tri-t-Bu-ester; (4) the coupling of two glycines to provide a spacer; and (5) the coupling of the amino acids as per the OP3-4 peptide sequence and subsequent Cys-Cys disulphide bond cyclisation.
