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. 2018 Jun 18;6(2):71. doi: 10.3390/biomedicines6020071

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The figure demonstrates the rationale for the quantification of depotentiation. Left panel corresponds to session type 1: LTP is induced by PAS and quantified. Right panel: In session type 2 LTP is induced by paired associative stimulation and shortly after depotentiated by variant continuous thetaburst stimulation. Depotentiation is quantified by calculation result of session type 1 minus result of session type 2.