Table 1.
Writers and erasers of H3K9 and H3K27 methylation. Histone Methytransferases (HMTs), Jumonji-C (JmjC) histone demethylases, and Lysine Specific Demethylases (LSDs) targeting H3K9 and H3K27 are shown (targets are in brackets). Euchromatic Histone Lysine Methyltransferase 2 (EHMT2, G9α), G9α Like Protein 1 (GPL), Suppressor Of Variegation 3–9 Homolog (SUV39H), SET Domain Bifurcated 1 (SETDB1), PR/SET Domain (PRDM), Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2), Lysine Demethylase (KDM), PHD Finger Protein (PHF), and Myc-Induced Nuclear Antigen (MINA).
| Writer | Eraser | |
|---|---|---|
| HMTS | JmjC Histone Demethylases | LSDs |
| G9α (H3K9/H3K9me1/me2) | KDM3A (H3K9me1/me2) | LSD1 (H3K9me1/me2) |
| GL9 (H3K9/ H3K9me1/me2) | KDM3B (H3K9me1) | (H3K4me1/me2) |
| SUV39H1 (H3K9me1/me2) | KDM4A (H3K9me2/me3) | LSD2 |
| SUV39H2 (H3K9me1/me2) | KDM4B (H3K9me2/me3) | (H3K4me1/me2) |
| SETDB1 (H3K9) | KDM4C (H3K9me2/me3) | |
| PRDM2 (H3K9) | KDM4D (H3K9me2/me3) | |
| PRDM3 (H3K9) | KDM4E (H3K9me2/me3) | |
| PRDM6 (H3K9) | KDM6A (H3K27me2/me3) | |
| EZH2 (H3K27/H3K27me1/me2) | KDM6B (H3K27me2/me3) | |
| KDM7A (H3K9me1/me2) | ||
| (H3K27me1/me2) | ||
| PHF2 (H3K9me1/me2) | ||
| (H3K27me1/me2) | ||
| PHF8 (H3K9me1/me2) | ||
| MINA (H3K9me3) | ||