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. 2018 May 22;11(2):50. doi: 10.3390/ph11020050

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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AM7410 is a potent and efficacious CB1 receptor agonist. (A) AM7410 inhibits excitatory neurotransmission in autaptic hippocampal neurons in a concentration-dependent manner. Maximal inhibition is similar to maximal inhibition from DSE in the same neurons; (B) Time course shows time course of inhibition of EPSCs after treatment with various concentrations of AM7410. Inset shows sample EPSCs before treatment and after treatment with 100 nM AM7410; (C) Sample time course shows absence of AM7410 effect in CB1^−/− neuron.