. 2018 Mar 31;6(2):17. doi: 10.3390/proteomes6020017

Table 1.

Regulatory factors of epithelial restitution and wound healing [49,52].

Action	Regulatory Factors
Inhibit cell proliferation	TGF-β
Inhibit cell proliferation	Activin A
Promote epithelial restitution via TGF-β dependent pathway	Epidermal growth factor (EGF)
	Glucagon-like-peptide-2 (GLP-2)
	IL-1
	IFN-ϒ
	IL-2
	HGF
	VEGF
	FGF
Promote epithelial restitution via TGF-β independent pathway	Trefoil peptides
	Galectin-2
	Galectin-4
	Keratinocyte growth factor (KGF)
Decrease epithelial restitution velocity	IL-13 [32]
Promote epithelial proliferation	Epidermal growth factor (EGF)
	TGF-α
	IL-6IL-22
Induce cell apoptosis	TNF-α
Prevent cell apoptosis	Prostaglandin E2