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Kinetic parameters for the metabolism of PROG to 17OH-PROG (17hydroxylation) and 17OH-PREG to DHEA (17,20 lyase reaction) by WT and V366M mutant of CYP17A1.
| CYP17A1 Variant | 17α-HydroxylasePROG to 17OH-PROG | 17,20 Lyase17OH-PREG to DHEA | |||
|---|---|---|---|---|---|
| Km (µM) | Vmax (min−1) | Cat Eff (%) | Km (µM) | Vmax (min−1) | |
| WT | 6.1 ± 0.7 | 0.71 | 100 | 0.92 ± 0.07 | 0.025 ± 0.004 |
| V366M | 8.4 ± 0.9 | 0.42 | 43 | - | - |
| S441P | - | - | - | - | - |
