Symbol	Explanation
B	A bit in the binary representation of an individual
$\widehat{F}$	Intervention size-scaled fitness
$F$	Objective fitness
$F_R$	Fitness of the best discarded individual
$\mu$	Specific growth rate
$N_B$	Number of bits per individual
$N_D$	Number of interventions per individual
$N_G$	Number of subsequent generations
$N_{GFE}$	Number of subsequent gene flow events
$N_P$	Population size
$N_{Pa}$	Number of possible pairs of individuals
$N_S$	Number of selected individuals
$N_T$	Number of target reactions
$R$	Mutation rate
$v_P$	Production rate
$v_S$	Substrate uptake rate
$X$	Selection rate
$y$	Trade-off factor