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IC50 values of compounds 2a–d, 4a–d and Melphalan against the A549 and HeLa cells.
| Compound | G | Ar | Cancer Cells IC50 (µM) | |
|---|---|---|---|---|
| (A549) | HeLa | |||
| 2a | -C(O)CH3 | C6H5- | >200 | >200 |
| 2b | -C(O)CH3 | 4-FC6H4- | >200 | >200 |
| 2c | -C(O)CH3 | 3-ClC6H4- | >200 | >200 |
| 2d | -C(O)CH3 | 4-MeOC6H4- | >200 | >200 |
| 4a | -NHC(O)CH3 | C6H5- | >200 | >200 |
| 4b | -NHC(O)CH3 | 4-FC6H4- | 116.2 ± 0.78 | 122.4 ± 1.02 |
| 4c | -NHC(O)CH3 | 3-ClC6H4- | 154.6 ± 0.90 | 126.9 ± 1.00 |
| 4d | -NHC(O)CH3 | 4-MeOC6H4- | 146.8 ± 1.00 | 125.0 ± 0.88 |
| Melphalan | - | - | 30.66 ± 0.76 | 37.16 ± 0.22 |
