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. 2018 Jun 11;11(2):59. doi: 10.3390/ph11020059

Table 3.

IC50 values of compounds 5a–h against A549 and HeLa cells.

graphic file with name pharmaceuticals-11-00059-i002.jpg

Compound G Ar Cancer Cells IC50 (µM)
(A549) HeLa
5a -C(O)CH3 C6H5- >200 >200
5b -C(O)CH3 4-FC6H4- >200 >200
5c -C(O)CH3 3-ClC6H4- >200 >200
5d -C(O)CH3 4-MeOC6H4- >200 >200
5e -NHC(O)CH3 C6H5- 9.94 ± 0.99 12.89 ± 1.11
5f -NHC(O)CH3 4-FC6H4- 5.03 ± 0.71 7.95 ± 0.90
5g -NHC(O)CH3 3-ClC6H4- 2.72 ± 0.43 8.74 ± 0.94
5h -NHC(O)CH3 4-MeOC6H4- 3.26 ± 0.51 10.72 ± 1.03
Melphalan - 30.66 ± 0.76 37.16 ± 0.22