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Expected mechanism of intracellular trafficking and release of the IM and Nil from the stimuli responsive PCL NPs (A). In vitro drug cumulative release of IM (B) and Nil (C) from wool-like IM/Nil loaded PCL NPs at 37 °C under neutral conditions (pH 7.4) and acidic conditions (pH 6.5 and 5.0). Representative measurements of three distinct sets of data have been reported no significant difference between values at different time points (Student’s t-test, P < 0.05).
