Table 3.
Pharmacokinetic parameters of procainamide and its metabolite, N-acetylprocainamide after intravenous administration of procainamide hydrochloride (10 mg/kg) in rats (mean ± SD, n = 5).
| Parameter | Procainamide | N-acetylprocainamide |
|---|---|---|
| AUClast (µg·min/mL) | 134 ± 12.5 | 156 ± 36.8 |
| AUCinf (µg·min/mL) | 136 ± 12.1 | 177 ± 29.6 |
| t1/2 (min) | 52.4 ± 2.20 | 131 ± 31.7 |
| MRT (min) | 28.5 ± 2.99 | 181 ± 38.3 |
| Vss (mL/kg) | 2070 ± 316 | - |
| CL (mL/min/kg) | 73.8 ± 6.51 | - |
| Cmax (µg/mL) | - | 0.949 ± 0.124 |
| Tmax (min) | - | 21.0 ± 8.22 |
| AUCNAPA/AUCPA ratio | 1.30 ± 0.191 | |