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. 2018 Apr 17;6(2):45. doi: 10.3390/biomedicines6020045

Figure 1.

Figure 1

Schematic representation of NF-κB circuitry, with particular emphasis on the negative feedback loops controlled by IκBs and A20 proteins. Such circuitry is extended to the control of a set of target genes IκBα, A20 and “Target” genes, suggesting that NF-κB dynamics can directly operate the dynamics of the transcriptional output.