Table 3.

Summary of non-safety in vivo phage cocktail studies. i.c.: intracavity wash; i.v.: intravenous.

Condition Targeted	Bacterial Species	Cocktail Composition	Results	References
Human Chronic otitis	P. aeruginosa	Biophage PA (six phages; BC-BP-01 to BC-BP-06) 105 PFU per phage	Clinical indicators improved in phage treated patients compared to placebo P. aeruginosa counts significantly lower in phage treated group compared to placebo	[86]
Human necrotic pancreatitis	Acinetobacter baumnnii	Three phage cocktails used; φPC (i.c.), φIV (5 × 109 PFU i.v.) and φIVB (5 × 109 PFU i.v.)	Patient survived and fully recovered Resistance to cocktails φPC and φIV after 8 days Phage serum concentration dropped to 20 PFU/mL after 120 min	[87]
Murine Bacteremia	Klebsiella pneumoniae	GH-K1, GH-K2, GH-K3	Cocktail reduced bacterial titre approx. 3–4log10 compared to monophage Cocktail counts decreased ≤2log10 in 90–120 min	[88]
Necrotic Enteritis of boiler chickens	Clostridium perfringens	C. perfringens phages (CPAS-7, CPAS-12, CPAS-15, CPAS-16and CPLV-42) in equal amounts	Mortality <1% when administered with water or feed. Compared to 64% in controls	[89]
Mouse model of mastitis	S. aureus	Twelve phage cocktail (composition unknown except for two phages; BP39 and mutant of ATCC 23361)	Bacterial counts approximately 4–5log10 in mammary tissue for cocktail treated group compared ≤2log10 for cefalonium treated control.	[90]