Table 4.

Overall Best Response Per RECIST V 1.1 and for Patients with Metformin Duration of > 5 Months (PR = Partial Response, CR = Complete Response, SD = Stable Disease, PD = Progressive Disease, ORR = Objective Response Rate, DCR = Disease Control Rate)

All Patients	No Metformin N = 33 (60%)	Metformin N = 22 (40%)
Best Response
PR	14 (42.4%)	9 (40.9%)	P = 0.39
CR	4 (12.1%)	6 (27.27%)
SD	2 (6%)	2 (9.1%)
PD	13 (39.4%)	5 (22.7%)
ORR	54.5%	68.2%	P = 0.31
DCR	60.6%	77.3%	P = 0.19
Median Time to Achieve Best Response (months)	2.7	2.8	P = 0.12
Metformin Duration of > 5 Months	No Metformin N = 33 (67.3%)	Metformin N = 16 (32.7%)
Best Response
PR	14 (42.4%)	5 (31.2%)	P = 0.12
CR	4 (12.1%)	6 (37.5%)
SD	2 (6%)	2 (12.5%)
PD	13 (39.4%)	3 (18.8%)
ORR	54.5%	68.7%	P = 0.34
DCR	60.6%	81.3%	P = 0.14
Median Time to Achieve Best Response (months)	2.7	3	P = 0.11