Table 2.

Differentially expressed genes in KKE 1.0 g/kg group compared to control group. Ten transcripts (8 transcripts were mapped to genes using Ingenuity Pathway Analysis) were differentially expressed in KKE 1.0 g/kg group using a false discovery rate of 5%. DNA microarray results were validated by QRT-PCR.

Gene ID	Gene name	Fold change	P value	Information related to retinal degeneration
Vipr2	vasoactive intestinal peptide receptor 2	−1.277	0.00E00	Protective effects of PACAP (ligand of Vipr2) in UV-A radiation-induced retinal degeneration models in rats (Atlasz et al. 2011). PACAP has protective effects in models of neurodegenerative diseases (Reglodi et al. 2011).
Usp29	ubiquitin specific peptidase 29	−1.228	0.00E00	USP29 removes ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. Ubiquitin (Ub) conjugation and degradation are increased in retinas isolated from light-exposed animals, and Ub may play an important role in protecting cells under stress conditions (Naash, Al-Ubaidi, and Anderson 1997).
Yy1	YY1 transcription factor	−1.218	0.00E00	YY1 increases the melatoninergic function of retinal photoreceptors (Bernard and Voisin 2008). In the retina, melatonin plays a key role in rhythmic photoreceptor metabolism and in regulation of the release of dopamine from post-photoreceptor neurons (Besharse, Iuvone, and Pierce 1988; Boatright, Rubim, and Iuvone 1994; White and Fisher 1989).
Scap	SREBF chaperone	1.145	0.00E00	SCAP regulates of cholesterol biosynthesis. Several cholesterol-related genes are risk factors for age-related macular degeneration (Pikuleva and Curcio 2014).

Sgtb, Etf4b, Rrm1 and Phtf2 were also differentially expressed in the KKE 1.0 g/kg group, however, there was no information on these genes that was related to retinal degeneration.