Table 2.
Incidence of uterine glandular epithelial lesions over time following neonatal exposure to GEN or DES.
| CON
|
GEN
|
DES
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (mo) | 2–3 | 6 | 12 | 18 | 2–3 | 6 | 12 | 18 | 2–3 | 6 | 12 | 18 |
|
|
|
|
||||||||||
| Diagnosis | Incidence (%) | Incidence (%) | Incidence (%) | |||||||||
| Glandular cystic dilation | 0/13 (0%) |
2/33 (6%) |
7/29 (24%) |
15/30 (50%) |
0/10 (0%) |
12/30b (40%) |
23/30c§ (77%) |
27/30b (90%) |
0/9 (0%) |
4/31 (13%) |
10/26 (38%) |
29/30c (97%) |
| Adenomyosis | 0/13 (0%) |
0/33 (0%) |
3/29 (10%) |
4/30 (13%) |
1/10 (10%) |
6/30b (20%) |
10/30 (33%) |
13/30a (43%) |
1/9 (11%) |
13/31c (42%) |
13/26b (50%) |
18/30c (60%) |
| Squamous metaplasia | 0/13 (0%) |
1/33 (3%) |
0/29 (0%) |
0/30 (0%) |
0/10 (0%) |
11/30c (37%) |
16/30c (53%) |
24/30c§ (80%) |
0/9 (0%) |
7/31a (23%) |
12/26c 46% |
14/30c (47%) |
| Severity grade | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | 0.8 | 1.2 | 0.0 | 0.3 | 0.6 | 0.8 |
| Basal cell metaplasia | 1/13 (8%) |
3/33 (9%) |
2/29 (7%) |
0/30 (0%) |
7/10b (70%) |
19/30c‡ (63%) |
26/30c (87%) |
30/30c (100%) |
8/9c (89%) |
30/31c (97%) |
25/26c (96%) |
29/30c (97%) |
| Severity grade | 0.1 | 0.1 | 0.1 | 0.0 | 0.7 | 0.7 | 1.7 | 1.7 | 0.9 | 1.5 | 2.0 | 1.7 |
| Atypical hyperplasia | 0/13 (0%) |
0/33 (0%) |
0/29 (0%) |
0/30 (0%) |
0/10 (0%) |
3/30‡ (10%) |
9/30b (30%) |
15/30c (50%) |
0/9 (0%) |
14/31c (45%) |
14/26c (54%) |
18/30c (60%) |
| Carcinoma | 0/13 (0%) |
0/33 (0%) |
0/29 (0%) |
0/30 (0%) |
0/10 (0%) |
2/30 (7%) |
7/30a (23%) |
10/30c (33%) |
0/9 (0%) |
5/31a (16%) |
9/26b (35%) |
12/30c (40%) |
Incidence data for 6, 12, and 18 mo time points were previously reported by Suen et al. 2016.
Abbreviations: CON, control; GEN, genistein; DES, diethylstilbestrol
Severity values indicate average grade across the entire group (0-4).
Letters indicate
a
P<0.05,
b
P<0.01, and
c
P<0.001 compared with corresponding age-matched control group using a two-tailed Fisher exact test.
Symbols indicate
§
P<0.05 and
‡
P<0.01 compared with corresponding age-matched DES group using a two-tailed Fisher exact test.