Table 1.
Formulation characterizations for propranolol hydrochloride nanostructure lipid carrier (NLC) according to full-factorial design and entrapment efficiency (EE%) (all concentrations are presented as w/v % and referred to total volume of suspension).
| Formulation No. | State in Full Factorial Design | Drug% | %L (Oleic Acid%) | Transcutol% | Surfactant% | Compritol% | EE% |
|---|---|---|---|---|---|---|---|
| 1 | +++ | 0.5 | 1.5 | 1 | 3 | 13.5 | 61.23 ± 3.12 |
| 2 | ++− | 0.5 | 1.5 | 0 | 3 | 13.5 | 58.13 ± 2.29 |
| 3 | +−+ | 0.5 | 0.5 | 1 | 3 | 14.5 | 48.98 ± 1.72 |
| 4 | −−+ | 0.5 | 0.5 | 1 | 1.5 | 14.5 | 28.53 ± 2.44 |
| 5 | −+− | 0.5 | 1.5 | 0 | 1.5 | 13.5 | 39.72 ± 3.05 |
| 6 | +−− | 0.5 | 0.5 | 0 | 3 | 14.5 | 45.11 ± 1.52 |
| 7 | −++ | 0.5 | 1.5 | 1 | 1.5 | 13.5 | 40.88 ± 2.25 |
| 8 | −−− | 0.5 | 0.5 | 0 | 1.5 | 14.5 | 35.95 ± 1.47 |