Table 3.

Different parameters regarding drug release from lipid nanoparticles (mean ± SD, n = 3). R4% and R48%: percentage of drug releaseed after 4 and 48 h.

Formulation No.	State in Full Factorial Design	R4 (%)	R48 (%)
1	+++	8.21 ± 0.37	23.38 ± 1.15
2	−++	5.4 ± 0.59	27.66 ± 1.38
3	+−+	8.45 ± 0.61	36.29 ± 1.57
4	+−−	20.71 ± 1.33	55.64 ± 4.11
5	−+−	10.4 ± 0.36	34.5 ± 3.05
6	−−+	14.5 ± 0.94	30.6 ± 1.96
7	++−	17.67 ± 1.42	42.2 ± 3.12
8	−−−	16.05 ± 0.95	41.17 ± 1.64