Table 5.

Parameter impacts on the permeability of different formulations of propranolol hydrochloride through cornea.

Formulation No.	State in Full Factorial Design	Q5 (mg/cm2)	Jss (mg/cm·s−1)	Tlag (h)	P (cm/s)
1	+++	0.7 ± 0.055	0.181 ± 0.012	0.95 ± 0.066	0.012 ± 0.002
2	−++	0.725 ± 0.038	0.178 ± 0.014	0.85 ± 0.09	0.0123 ± 0.0014
3	+−+	0.761 ± 0.062	0.185 ± 0.016	1.05 ± 0.095	0.015 ± 0.0009
4	+−−	1.705 ± 0.12	0.493 ± 0.025	0.95 ± 0.059	0.068 ± 0.001
5	−+−	1.220 ± 0.088	0.331 ± 0.014	0.88 ± 0.072	0.033 ± 0.0001
6	−−+	0.625 ± 0.055	0.155 ± 0.009	0.75 ± 0.083	0.014 ± 0.0006
7	++−	1.42 ± 0.13	0.417 ± 0.027	0.95 ± 0.047	0.041 ± 0.0008
8	−−−	0.885 ± 0.035	0.24 ± 0.017	1.10 ± 0.087	0.027 ± 0.0005
Control	−	0.229 ± 0.011	0.053 ± 0.002	0.85 ± 0.069	0.002 ± 0.00005