Table 3.
Univariate and multivariate analyses of prognostic variables for overall survival
| Variables | Univariate analysis
|
Multivariate analysis
|
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age, years | 0.991 | 0.985–0.997 | 0.004 | |||
| Gender | 0.872 | 0.684–1.112 | 0.268 | |||
| HBsAg | 1.177 | 0.957–1.447 | 0.123 | |||
| AFP | 1.252 | 1.046–1.499 | 0.014 | |||
| Cirrhosis | 0.974 | 0.799–1.187 | 0.794 | |||
| Tumor size, cm | 1.641 | 1.368–1.969 | <0.001 | 1.382 | 1.146–1.666 | 0.001 |
| Tumor multiplicity | 1.634 | 1.395–1.915 | <0.001 | |||
| Differentiation | 1.625 | 1.238–2.134 | <0.001 | |||
| TNM | 2.074 | 1.771–2.429 | <0.001 | 1.774 | 1.497–2.193 | <0.001 |
| Vascular invasion | 2.594 | 2.146–3.136 | <0.001 | 1.785 | 1.453–2.193 | <0.001 |
| Involucrum | 1.373 | 1.176–1.603 | <0.001 | 1.189 | 1.013–1.395 | 0.034 |
| PPARα (cytoplasm) | 1.593 | 1.276–1.989 | <0.001 | 1.595 | 1.274–1.997 | <0.001 |
| PPARα (nucleus) | 1.612 | 1.033–2.517 | 0.036 | |||
Abbreviations: HR, hazard ratio; PPARα, peroxisome proliferator-activated receptor α; HBsAg, hepatitis B virus surface antigen; AFP, α-fetoprotein.