Figure 4.

Comparison of confidence and prediction intervals calculated by different methods. (a) The 95% confidence interval width of total lymphocyte counts (i.e., the difference of the 2.5th and the 97.5th percentile from the predicted value) f (c, $\widehat{\theta }$). Concentration values are indicated by ticks at the top of the panel. (b) The 95% prediction intervals. Observed data are indicated as circles. The 1,000 simulations (simulation approach) and 1,000 parameter re‐estimations (simulation‐estimation approaches) were performed.