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. 2018 Jun 28;19:505. doi: 10.1186/s12864-018-4873-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The derived interlogs between M. tuberculosis H37Rv drug-resistant genes and human genes. a illustrates the interactions of M. tuberculosis H37Rv drug-resistant genes involved in cytochromes and other target-modifying enzymes that could cause potential chemical modification of drug molecules [46]. b illustrates the interactions of M. tuberculosis H37Rv drug-resistant genes involved in SOS-response and DNA replication that lead to mutations in the gene or its regulatory region. The light blue circles denote M. tuberculosis H37Rv genes and the red diamonds denote human genes [46]