Table 6.

GO and pathway enrichment analysis of the M. tuberculosis H37Rv genes that are predicted to target human TNF-alpha and IL-1~IL11 signaling pathways

TNF-Alpha	GO term ID	GO aspect	GO term name	%	Shared
MTB genes that target human gene PSMC2	GO:0005524	F	ATP binding	26.92	Yes
	GO:0016020	C	membrane	20.51	Yes
	GO:0055114	P	oxidation-reduction process	16.67	No
	GO:0016310	P	phosphorylation	5.98	No
	GO:0006412	P	translation	5.13	No
	GO:0055085	P	transmembrane transport	2.14	Yes
	GO:0046933	F	hydrogen ion transporting ATP synthase activity, rotational mechanism	1.71	No
Human gene PSMC2	GO:0002479	P	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	–	–
	GO:0043687	P	post-translational protein modification	–	–
	GO:0045899	P	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	–	–
Targeted human genes	CASP10,BID,RUVBL2,DDX21,RPL4,BRINP1,PSMC2,PSMD1,FANCD2,MTIF2,PSMD2,PSMB5,RPS11,PSMC3,GLUL,PDCD2,KTN1
IL-1 ~ IL-11	GO term ID	GO aspect	GO term name	%	Shared
M.TB genes that target the human gene VCP	GO:0003824	F	catalytic activity	32.17	No
	GO:0016021	C	integral to membrane	16.78	No
	GO:0005524	F	ATP binding	27.27	Yes
	GO:0055114	P	oxidation-reduction process	9.79	No
	GO:0006810	P	transport	3.50	Yes
	GO:0006281	P	DNA repair	2.10	No
Human gene VCP	GO:0005515	F	protein binding	–	–
	GO:0006914	P	autophagy	–	–
	GO:0016236	P	macroautophagy	–	–
	GO:0010918	P	positive regulation of mitochondrial membrane potential	–	–
	GO:0006974	P	cellular response to DNA damage stimulus	–	–

Targeted human genes BCL2L11,UNC119,IRS1,IL2,DOK2,PTPN6,BAD,IL11,VCP,IRS2

C denotes cellular component, F denotes molecular function, and P denotes biological process